Hello Nature readers,
Today we hear how the blood of a man who’s been bitten by snakes 200 times is being used to make a potent antivenom, track Trump’s dismantling of US science and probe the mental-health effects of increasingly sophisticated ‘AI companions’.

Blood, sweat and antivenom

The blood of a snake fancier who has been bitten by venomous snakes hundreds of times has been used to develop a potent antivenom. The therapy protects mice against the venoms of 19 species of dangerous snake, including the deadly king cobra (Ophiophagus hannah). The research could lead to direly needed treatments, scientists say. However, its reliance on material from a person who performed dangerous experiments on himself makes it ethically murky. “We did not advise Friede to do this and no one else needs to do this again,” says co-author Jacob Glanville, chief executive of biomedical firm Centivax.

Mutation linked to lower need for sleep

From Thomas Edison to Benjamin Franklin, history is speckled with luminaries claimed to be able to thrive on as little as three hours of sleep. Now scientists have identified genetic mutations that probably contributes to some people’s limited sleep needs. One mutation, when genetically engineered into mice, caused the animals to sleep half an hour per day less than their unmodified brethren.

Human gut fungus slows liver disease

Fusarium foetens, a common fungus in our gut microbiome, produces a molecule that reduces the symptoms of non-alcoholic fatty liver disease in mice. This finding marks a step toward new treatments for the disease, which affects roughly 30% of adults worldwide.

Trump proposes huge cuts to science

US president Donald Trump’s proposed budget for fiscal year 2026 calls for unprecedented cuts to scientific agencies and targets work in areas including climate change, clean energy and the social, behavioural and economic sciences. The proposal suggests cutting roughly half the budgets of the US National Science Foundation, the US National Institutes of Health and the Environmental Protection Agency, which on Friday also announced plans to dismantle its primary research division. NASA would also lose about a quarter of its funding. Ultimately, Congress — which is controlled by a majority from Trump’s Republican party — will decide how the federal budget will be spent.

Exclusive: NSF stops all new grants

Staff members at the US National Science Foundation (NSF) were told on 30 April to “stop awarding all funding actions until further notice,” according to an email seen by Nature. The policy prevents one of the world’s biggest supporters of basic research from awarding new research grants and from supplying additional increments of money or subawards to existing grants. Researchers should be able to draw down money from grant funds that they have already received, NSF staff members say. “This country’s status as the global leader in science and innovation is seemingly hanging by a thread at this point,” one NSF staffer says.

US climate-report authors vow to go on

The Trump administration has dismissed hundreds of scientists working on an influential report that outlines to federal and local governments how best to deal with the impacts of climate change. But they’re not giving up. “I volunteered for this effort, and I’m ready to continue it,” says systems engineer Costa Samaras, the lead author of a chapter of the National Climate Assessment. This echoes the commitment made last month by contributors to the National Nature Assessment, which was to have been the first nationwide look at US lands, water, wildlife and ecosystems. Given that the climate report is mandated by Congress, some worry that Trump's team might produce a watered-down version that plays up climate-denial views.