Hi Jan,

At the clinic, we don’t just recommend protocols—we test them ourselves.

This month, we’re pulling back the curtain on a deeply personal case: Dr. Scott’s decades-long struggle with brain fog, fatigue, and the stubborn aftereffects of mold exposure. Despite extensive detox protocols—including a full year of binders and a course of antifungals—his lab results remained unchanged.

So he tried something different.

Could mold have colonized his sinuses?

With a history of chronic sinus infections as a child, Dr. Scott had a hunch. Inspired by research showing that mold can take up residence in the sinuses—and that antifungal sinus treatments can dramatically reduce symptoms—he started a new protocol:

Atomized Amphotericin B + EDTA (to dissolve biofilms and kill mold)

A specialized atomizer for deeper sinus delivery

A test-retest plan to monitor progress with urinary mycotoxin testing

The results? Extremely promising.

The first two weeks of treatment weren’t easy. Dr. Scott experienced what’s known as die-off symptoms—a temporary spike in fatigue, brain fog, joint pain, and intense sinus pressure. One day even brought on the worst headache of his life.

But rather than being discouraged, he saw this as a promising sign.

Why? Because the only way a nasal antifungal like amphotericin B could cause systemic symptoms is if it’s actively killing mold. And that means the mold was likely there all along.

By week three, the die-off symptoms subsided—and that’s when things shifted.

His cognitive clarity returned

His mood lifted

He had energy after work to play with his 3-year-old daughter and 9-month-old son

He felt better—and noticeably so

For Dr. Scott, this wasn’t just a small improvement. It was a turning point.

Why share this?

Because at our clinic, we’re always learning. We believe in science, data, and treating the whole person—and that includes exploring lesser-known causes of persistent symptoms like mold colonization.

If you’ve struggled with brain fog, fatigue, poor memory, mood swings, insomnia, headaches, sinus issues, gut symptoms, food sensitivities, or joint pain, mold could be playing a role—even if your labs are normal or you don’t recall a major exposure.

At our clinic, we look deeper. And when standard approaches fall short, we test what actually moves the needle.

Want support for mold-related symptoms?

We can help you test, treat, and track your progress with the same tools we use ourselves.

Schedule an Appointment →

In Health,

Dr. Michael Ruscio, DC

Adjunct Professor, University of Bridgeport
Clinical Researcher