Rush University System for Health plans to dramatically expand its clinical trials for patients with cancer thanks to a major donation from the family foundation of late business leader Harold B. Smith, the system announced Thursday.

The harbor lock is one of the nation’s busiest for both commercial and recreational use; more than 900,000 passengers and 80,000 vessels traveled through it last year. But looming federal funding cuts have become a source of worry for boaters who rely on the lock.

The State/Lake ‘L’ station in the Loop will close starting Jan. 5, the Chicago Department of Transportation said Thursday.

“It’s a story of 100 years of Americana, and really a rich story of 100 years of cycling as well,” said Daniel Clarke, the filmmaker responsible for the documentary.

An advocate for rideshare drivers first emailed the city on Sept. 19. But the city did not appear to take any action until a raid at the parking lot three weeks later.

This top-floor unit at 900 W. Washington Blvd. in Chicago offers skyline views from a wraparound terrace.

A new organization set to represent downtown Aurora businesses and property owners, planned to be similar to one that joined with other groups to form the Aurora Regional Economic Alliance, is now in the early stages of being formed.

Here’s a look back at what happened in the Chicago area on Dec. 4, according to the Tribune’s archives.