The Phase 3 PSMAddition trial found that 177Lu-PSMA-617 in combination with androgen deprivation therapy and androgen receptor pathway inhibitors was associated with improved radiographic progression-free survival in patients with PSMA-positive metastatic hormone-sensitive prostate cancer. The trial, involving 1,144 patients, also showed a trend towards overall survival benefits, according to a presentation at the 2025 Society of Urologic Oncology conference.

A study in the journal Movement Disorders found that Parkinson's disease can disrupt the connection between dopamine neurons and synapses in key brain regions, using PET imaging to highlight differences from healthy brains. The 30 patients in the study who had Parkinson’s disease, and 13 healthy volunteers, had two PET scans to assess dopamine transporters and synaptic density.

Research in Nature Neuroscience identified microglial activation as important for amyloid-beta to promote reactive astrogliosis, amplifying neuroinflammatory responses. The research highlights the role of microglia in modulating the amyloid-driven neuroinflammation, which is a key factor in Alzheimer's disease progression. The study included 101 people who had plasma analyses of p-tau217 and glial fibrillary acidic protein, and PET imaging of amyloid-beta, translocator protein and tau, and the data were validated with an additional 251 people using soluble TREM2, a biomarker of microglial activation in the cerebrospinal fluid.

A study found that secondary interpretations of pediatric nuclear medicine exams resulted in meaningful changes in 17% of cases, potentially affecting clinical management. "A substantial fraction of these changes were complete changes in interpretation from benign/negative to the presence of malignant disease, or vice versa," researchers wrote in a radiology journal.

Telix Pharmaceuticals and Siemens Healthineers' Varian are collaborating to develop clinical applications that combine Telix's theranostics with Varian's external beam radiation therapy technology. Telix's prostate cancer PET imaging agents may be used to help select patients for EBRT and develop personalized treatment plans.

US medical school enrollment has surpassed 100,000 for the first time, driven by a 5.3% increase in applications, according to the Association of American Medical Colleges. The surge comes amid projected physician shortages, with first-year enrollment rising 1.2%. Women make up 57.2% of applicants, but socioeconomic diversity among students is declining.

A study in a radiology journal found that targeting women eligible for both lung and breast cancer screening can increase the number of lung cancer screening exams conducted. Researchers identified women eligible for lung cancer screening through mammography programs and offered simultaneous screenings or direct outreach.

The International Conference on Radiation Protection in Medicine is taking place this week in Vienna to address the evolving challenges of radiation safety in medical applications. Organized by the International Atomic Energy Agency and co-sponsored by the World Health Organization and the Pan American Health Organization, the event brings together more than 670 participants from more than 120 countries.