Dear Colleagues, Students, and Friends,

Most “stuck cases” aren’t stuck because you don’t know enough biochemistry.
 

They’re stuck because the patient’s control systems won’t allow healing to proceed.

Here’s the simplest way I teach FM 2.0:

How to use this today (clinically):

When a patient isn’t improving, don’t just add more protocols—ask: 

Which pillar is blocking progress?

Start with State/ANS + Circadian Timing (sleep, stress physiology, light timing) before escalating interventions.

Use Mitochondria/CDR + Redox + Neuroimmune regulation to guide sequencing and tolerance.

Save this graphic. 

It’s a quick “stuck-case checkpoint” you can return to anytime progress stalls.
 

Over the next few emails, I’ll walk through each pillar with the 1–2 questions that identify what to address first.

Sincerely,

Ron Grisanti, D.C., D.A.B.C.O., D.A.C.B.N., M.S., DIANM, CFMP

Founder, Functional Medicine University

P.S. If these Evolution of Functional Medicine trainings are resonating and you’d like a structured, step-by-step path to apply this level of upstream, root-cause thinking in your own practice, the next Functional Medicine University cohort opens in January 2026. You can hold your seat with a $150 deposit so you don’t miss the enrollment window. Learn more or reserve your seat here by clicking here

P.P.S. Know a colleague who would appreciate this? If this email was valuable, please forward it to one clinician or health professional who is committed to true upstream, root-cause functional medicine. If this email was forwarded to you and you’d like to receive the full Evolution of Functional Medicine series and future trainings directly from me, you can join my email list by clicking here