Arizona investigators probing the disappearance of Nancy Guthrie, "TODAY" co-anchor Savannah Guthrie's mother, said they believe she was taken from her home against her will.

Pima County Sheriff Chris Nanos previously described Guthrie’s home as a "crime scene." She was taken “possibly in the middle of the night and that includes possible kidnapping or abduction,” his department said in a statement.

Guthrie, 84, was last seen Saturday night in her home outside Tucson. She has limited mobility and needs to take medication daily or "it could be fatal," Nanos said.