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Thursday, 5 February 2026
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The Big (GLP-1) Game
The Super Bowl is once again getting the GLP-1 ad treatment.
Hims & Hers is back with another combative spot that calls out the disparities in healthcare experiences between the rich and, well, the rest of us. The company positions itself as the great equalizer, able to bring care typically reserved for wealthier patients (like microdosed GLP-1 weight loss drugs and preventive cancer screenings) to the masses.
But it’s Ro’s Super Bowl ad debut — and a fascinating blog from its CEO about the commercial’s cost and potential benefits — that I want to talk about. Ro’s campaign stars Serena Williams, who shares her progress using a GLP-1 drug through Ro: "34 pounds down," "healthier," and "moving better," she says, as she injects the medicine into her arm and dances on a blue platform. (Williams’ husband, Reddit CEO Alexis Ohanian, is a Ro investor and board member.)
In the blog post last week, Ro CEO Zachariah Reitano talked about why the company decided the pricy ad was worth it. He said he wrote the post because people tend to think such ads are "extravagant or irrational."
According to Reitano, 30-second Super Bowl ads cost anywhere from $9 million to $16 million, when considering the cost to produce it and run it during the game. Companies that buy the ads are required to spend an equivalent amount to run it on other network programs, so Ro’s spot will also run during NBC’s Winter Olympics broadcast. All in, companies typically commit up to $23 million, he said.
It’s a pretty chunk of change, but with big upside. It could reach more than 100 million people, drive an immediate influx of new customers, lower the company's customer acquisition costs, and make it more likely that people sign up when they see a future Ro ad.
The bet is probably a safe one. Direct-to-consumer telehealth companies have been prolific advertisers on social media, TV, podcasts, you name it — and it’s worked. Millions of patients are buying GLP-1 drugs with cash instead of insurance. This week, Novo Nordisk officials said cash-pay makes up around 30% of prescriptions for the Wegovy shot. Eli Lilly said about a third of new patients who start on an obesity drug choose the cash-pay Zepbound vials. That’s to say nothing of what’s likely millions of people buying compounded GLP-1s (which Hims sells, but not Ro). 
With the Super Bowl ads, the cash-pay market stands to grow even bigger. And Hims today announced that it's launching compounded Wegovy pills — stay tuned for more on that. Which companies will be the biggest beneficiaries of that growth remains to be seen.
- Shelby
P.S. - I’m heading to DC next week for the ASTP Annual Meeting. Let me know if you’ll be there!
Here’s what’s new
Hims adds Grail's cancer test amid questions about widespread use
Hims & Hers is bring­ing Grail's can­cer test to its con­sumer health plat­form, mark­ing a sig­nif­i­cant step to­ward mass adop­tion of a tech­nol­o­gy that's shown progress while re­main­ing un­der sci­en­tif­ic de­bate.
Midi Health raises $100M as it plans expansion into urgent care, research
Health tech’s lat­est uni­corn is Mi­di Health, a women’s health start­up launched dur­ing the pan­dem­ic that has since ex­pand­ed in­to broad­er vir­tu­al care with a re­cent fo­cus on longevi­ty.
'Turning around the Titanic': How the incoming PBM reforms will transform CMS
The Cen­ters for Medicare and Med­ic­aid Ser­vices has nev­er played a sig­nif­i­cant role in reg­u­lat­ing phar­ma­cy ben­e­fit man­agers, the mid­dle­men that have his­tor­i­cal­ly re­lied on high drug prices for prof­its. But the gov­ern­ment spend­ing pack­age is poised to change that.
Cold hard cash
30 The percentage of prescriptions for Wegovy shots being paid for with cash instead of insurance, Dave Moore, Novo Nordisk’s executive vice president of US operations, said during the drugmaker’s fourth-quarter earnings call Wednesday.
This week in health Тech
Lotus Health AI raised $35 million for a free, AI-powered primary care platform that generates diagnoses and treatment guidance. Human doctors then review and prescribe medication as needed. The Series A was led by Kleiner Perkins and CRV.
Alaffia Health raised a $55 million Series B led by Transformation Capital. The startup uses AI to help health plans review insurance claims.
The founders of Fitbit launched a new startup called Luffu to help families keep track of each other's healthcare, including doctor visits, lab tests, medications, diet and health stats. The company says it uses AI to monitor changes and provide guidance.
In addition to PBM reforms, the spending bill President Donald Trump signed Tuesday extends Medicare telehealth flexibilities through 2027. It also extends a waiver allowing providers to deliver hospital-level care at home through 2030.
Synthpop raised $15 million to automate healthcare administrative tasks such as referrals, claims follow-ups and prior authorizations. The Series A was led by Ansa Capital; among the other investors was former Humana CEO Bruce Broussard.
Graici, a startup automating Medicaid renewals and redeterminations, raised $7.5 million. The Series A was led by Santé Ventures.
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