In this edition: One family's Alzheimer's fight and how younger Americans define success

One family’s fight against early-onset Alzheimer’s. Three siblings in a family with a history of a rare genetic mutation that virtually guarantees the carrier will die of an aggressive form of Alzheimer’s have enrolled in a clinical trial to see if the disease can be slowed or halted.

What Medicaid work requirements mean for enrollees. Policy analysts expect millions of Americans to lose coverage because of cumbersome paperwork, bureaucratic hurdles and noncompliance.

Is your brain aging faster than you? Brain function and cognition significantly improved in patients who altered their diet and exercise habits in a study testing whether lifestyle changes could reverse early-stage Alzheimer’s disease.

Younger adults are redefining success. Americans who have yet to reach middle age rank physical and mental health ahead of wealth, status and occupation as the top measures of success.

Moderna rallies and AbbVie strikes a deal.  Moderna shares rallied after its messenger RNA flu vaccine candidate showed positive results in a late-stage trial and AbbVie agreed to acquire Capstan Therapeutics for $2 billion in cash.

Centene faces earnings crunch. The end of certain pandemic-era health-insurance benefits is prompting more Americans to drop out of coverage plans, which could hollow out the company's earnings. On top of that, Medicaid cuts would limit the number enrollees in its largest business.

This newsletter was compiled by the WSJ’s Health & Science team. Follow us on X @WSJHealth and @WSJScience. Email us by replying to this newsletter.