Why Your Morning Coffee Isn't Working(unless you are Marc Andreessen)
Most energy drinks just dump caffeine in your system to block adenosine. You feel alert for a bit, then your cortisol spikes and you crash. Not ideal.
Better move: pair caffeine with L-theanine. It promotes alpha-wave activity, which means you get the boost without feeling like you're vibrating. Matcha does this naturally: slower uptake, fewer jitters, steadier focus throughout the day.
Here's what actually helps:
Citicoline keeps your attention sharp
Bacopa helps with memory (takes a few weeks to kick in)
Lion's mane supports nerve growth (still early research, but promising)
Rhodiola and cordyceps help you handle stress without frying your nervous system
Add some turmeric and vitamin C to deal with oxidative stress. B-vitamins keep your cells running...
The best ready-made formulation I've found which achieves this and more is Magic Mind, it packs all of this into one shot (matcha, L-theanine, nootropics, adaptogens, the complete package). It's designed for mental performance without the crash or the pill fatigue.
They say don't get high on your own supply, but we're sure glad Dalibor Sames did. Dalibor is a psychedelic chemist who edits natural compounds in order to keep the medicine and delete the risk. And after 20+ years of studying ibogaine, he decided to go to a verified clinic in Mexico to try it for himself. What he experienced gave him a deeper understanding of ibogaine's potential and even more reason to keep pushing for it to become a cure for addiction, a facilitator of re-connection, and a simulator of possibility. And yes, it's exactly as wild as it sounds.
Michael Bloomberg got fired at 39, took the payout and used it to build one of the biggest private companies in the world. David Senra breaks down the lessons behind Bloomberg’s story, from why sales matter to why five year plans are overrated and how small moves can lead to massive results
Keytruda (pembrolizumab) reshaped modern oncology treatment and generated $31.7 billion of revenue in 2025 alone. However, it didn't become the best-selling cancer drug of all time overnight. Part one of this Podcast Notes Premium Series explains why immunotherapies were blackballed by big pharma for almost 100 years, how scientists discovered that the immune system can be driven like a racecar, why you should never ignore a serendipitous discovery, and how a Russian-nesting-doll of mergers and acquisitions nearly buried the drug that would eventually become Keytruda
It took almost 100 years for neuroplasticity to replace the views of Santiago Ramon y Cajal
Neuroplasticity: “The adult brain’s ability to change, rewire, and heal itself”
“Synapses are the common denominator of most, if not all, disorders of the XXXX”
Synapses: Where communication occurs between XXXX in the brain
Synaptic dystrophy: Loss or damage to XXXX is common for neurodegenerative disorders (e.g. Alzheimer’s) and mental health conditions (e.g. depression)
Synaptic pruning deficit: Formation of too many synapses that cannot be properly pruned may be connected to XXXX
XXXX can cure addiction within a few hours of a single dose?
GDNF: Glial cell-derived neurotrophic factor is a natural protein that nurtures dopamine neurons, and XXXX can manipulate the brain’s systems to trigger its release (h/t Deborah Mash)
“Within a few hours the dependence on [opioids, cocaine, and alcohol] is basically XXXX”
Dalibor took a “flood dose” of ibogaine at 10mg/kg which led to a XXXX hour experience
“For me, it was very visual and auditory. I felt like I was XXXX and to me it was a scientific pilgrimage to be in the right with ibogaine. It was very emotional. It was very exciting.”
A common subjective experience with ibogaine is the feeling of “being XXXX” which is something Dalibor felt and aligns with the hypothesis that ibogaine is a systems molecular technology
The experience can be extremely XXXX. Some people just see a “void” and don’t notice any visual or auditory effects. Some people literally sleep through the whole thing.
Dalibor is now in the process of XXXX his experience scientifically and processing it emotionally
He’s currently XXXX the molecular structures he visualized, but there were also symbolic and creative aspects of the experience that he still needs to decode and interpret
“It was a great experiment. It really advanced the way I plan experiments and think about the field… It’s not just intellectual now, it’s experiential, emotional, and almost spiritual.” He feels much more XXXX now, with his work and family.
He actually stopped drinking alcohol as well. He used to have a glass or two of wine with dinner, but he just doesn’t find it XXXX anymore. Which is odd, because nothing about his ibogaine experience had anything to do with alcohol. However, it could just be evidence of ibogaine’s power over treating the hallmarks of addiction, no matter how severe
Bloomberg had a very direct strategy early in his career: get in before everyone else, stay later than everyone else and become useful to the people making decisions
He got to work at 7 a.m. so he would be there before almost everyone except the boss, Billy Salomon
When Billy wanted to talk sports, borrow a match or make an after hours call, Bloomberg was there
“Making myself omnipresent wasn’t exactly burdensome. I loved what I was doing”
At 26, he had become close with the managing partner
He says he never understood why everyone else did not try to make themselves indispensable too
This is not about pretending to work late for attention… it is about becoming the XXXX
The cancer idea that spent decades on the sidelines
Using the immune system to fight cancer dates back to the 1890s, but radiation and chemotherapy pushed immunotherapy aside for most of the 20th century
By the 1960s, scientists could still be mocked for seriously discussing T cells
It took nearly a century for the once-dismissed idea to become the basis for the world’s biggest cancer drug
The breakthrough came from treating T cells like a XXXX
Researchers learned that T cells have both an accelerator and a brake: CD28 tells them to go, while CTLA-4 prevents them from attacking XXXX
Jim Allison asked whether cancer was exploiting that XXXX to protect itself
When his team blocked CTLA-4 in mice with tumors, every treated mouse became XXXX