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​NEW Premium Notes​

​Andrew Huberman: Energy, Sleep, and Why AI Companies Could Become Biotech Companies | Invest Like the Best​

• Patrick O’Shaughnessy sits down with Andrew Huberman to discuss practical stuff on sleep and energy, some frustration with how overcomplicated health advice has become, and a lot of excitement about where brain technology is going. These premium notes will teach you the three things to work on to fall asleep and what you need to think about when choosing work you actually want to do​

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​Charlie Munger’s Lost Interview with Todd Combs | The Knowledge Project (Outliers)​

• Shane Parrish dissects a never-before-seen interview with Charlie Munger, conducted by Todd Combs as part of the 2022 Singleton Prize for CEO Excellence ceremony. Even though this interview has been collecting dust on the shelf for several years now, its wisdom is ripe for the present. Expect to learn the skills Munger took away from legendary operators, how to find problems worth solving, and some investing lessons that feel more like life lessons

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​Keytruda (Part 4/4): How Merck’s Pembrolizumab Became the Best-Selling Cancer Drug of All Time | Approved with Alex Kesin and Matthew Pech​

• Part four of this Podcast Notes Premium Series explains why PD-1 was a scientific one-hit wonder in immuno-oncology, how much Keytruda has increased survival rates in lung cancer, and how Keytruda has grown into a $30 billion per year moat for Merck. To conclude, hosts Alex and Matthew grade Keytruda on its impact on patients, financials, academics, and one bonus category

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Top Premium Takeaways Of The Week

​Andrew Huberman: Energy, Sleep, and Why AI Companies Could Become Biotech Companies | Invest Like the Best​

How to fall asleep faster and sleep better

• Avoid these
  • Drink caffeine too late
  • Be under too much bright light late in the day
  • Use alcohol or cannabis to get to sleep
• Work on these:
  • Turn your thoughts off
  • Slow your XXXX​
  • Forget about the position of your XXXX in space

• Move from thinking and planning into XXXX. Notice your XXXX…
• You are not trying to concentrate on your XXXX the whole time. Let your attention move between XXXX, then come back when you notice yourself XXXX​

The dark side of health XXXX​

• The bar for entry is basically zero. Someone shows their abs or glutes, gets a following, and starts XXXX​
• What he loves about Tim Ferriss is that he talks about the things he wishes he hadn’t done and the things he’s XXXX​
• People come in with basically no science or health training and say they know how to optimize the mind and body because they used to XXXX​
• You have to be true to yourself, but you also have to take the XXXX seriously
• “It’s very easy to get attention. It’s very hard to keep XXXX”

Meta, OpenAI, and Anthropic will go beyond XXXX​

• “Every single one of those is going to be a XXXX company”
• The coolest problem, and the biggest problem, is how to write to the nervous system without opening the XXXX​
• Getting people with locked in syndrome to speak, or people with spinal injuries to walk, is XXXX​
• They’re all interested in the XXXX​
• The big questions are about XXXX​
  • How can you stimulate a XXXX in the right place and at the right time?
  • How can you quiet that XXXX?
  • How can you dial up or down the level of XXXX?

• You still have to understand your field and do the difficult work. Experiments, building a company, and doing a podcast properly are all XXXX​
• Make sure it’s work you XXXX​
• The tragedy is moving away from your genuine curiosity because you’re trying to XXXX​

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​Charlie Munger’s Lost Interview with Todd Combs | The Knowledge Project (Outliers)​

Work only on problems that have an answer

• “I don’t like unlimited failure and I don’t want to fish forever and never catch a fish”

Work long enough and you’ll find the answer

• “What I am is a guy who’s been able to take moderate obsession and a long attention span and turn them into XXXX” – Charlie Munger

The answer often lies in XXXX​

• Munger found his window design for college dormitories by copying XXXX​

Your answer may be in turning a perceived XXXX into a surprising XXXX​

• Nobody wants a room on the inside portion of a XXXX, right? Wrong.
• Disney XXXX actually charged more for rooms with artificial windows
• The XXXX could do things that a real XXXX could not (e.g. display personal messages)

Golden rules of investing (and life):

• If you can invest in a great company early, then stay in it for XXXX​
  • “That’s the easiest, biggest money you’ll possibly make”
  • Companies get bid up so high, so fast that these can be XXXX​
  • Don’t expect to find 30 winners, you want XXXX​
• You should give yourself a hypothetical “investment XXXX”
  • If you knew you could only make 20 investments in your life, you’d be more comprehensive about your XXXX​
  • ​XXXX makes it so easy and tempting to make investments immediately and without proper research
• You must keep your XXXX when everyone else is losing theirs
  • Investing cycles require constant XXXX​
  • ​XXXX fuel overconfidence and busts fuel irrational fear
  • “XXXX” will protect you from this “self-enforcing feedback loop”
• Read the rest HERE​