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How effective is Ozempic, really? Let’s look at the science.

Ozempic has been making waves lately for its effects on blood sugar control and weight loss. Originally designed to help manage type 2 diabetes, it works by helping your body regulate insulin and slowing digestion, which can reduce cravings and promote weight loss.

HOW DOES OZEMPIC WORK?

Ozempic (semaglutide) activates receptors that help control blood sugar and insulin levels. It also slows down how quickly food moves through your stomach, helping to curb appetite. While this can aid weight loss, the effects tend to be moderate, with research showing an average weight loss of about 6–7 pounds over a year.

Additionally, Ozempic requires a lifelong commitment. A 2022 randomized controlled trial found that a year after discontinuing semaglutide, participants regained two-thirds of the weight they had lost. So it isn’t a quick fix for long-lasting weight loss.

POTENTIAL SIDE EFFECTS

The most common concerns with Ozempic are digestive issues like nausea, diarrhea, and constipation. About 12% of users report constipation, which can make it uncomfortable for some. Staying hydrated, eating fiber-rich foods, and regular movement can help manage these symptoms.

ARE THERE ALTERNATIVES?

For those looking to manage blood sugar or lose weight without medication, lifestyle changes remain the most effective approach. Balanced diets like Mediterranean, Paleo, or low-carb, combined with regular exercise, can support your goals naturally.

Another alternative that’s gaining attention is berberine. Sometimes called “nature’s Ozempic,” berberine helps regulate blood sugar by improving insulin sensitivity and has anti-inflammatory benefits. While we don’t yet have data directly comparing berberine to Ozempic, a 2021 meta-analysis of 46 randomized controlled trials showed that berberine lowered blood sugar levels to a similar degree as metformin, a well-established type 2 diabetes drug. When combined with metformin, these benefits were even greater. It’s a more affordable, natural option that may be worth considering if you’re looking for a different path.

At the end of the day, building a foundation of healthy habits is key. Medications like Ozempic can be useful, but they’re not a one-size-fits-all solution. Consider starting with the basics: nutrition, movement, and stress management. Then explore natural options like berberine if you want to take a more holistic route. And if you need any guidance along the way, reach out to the clinic, we would love to help you.

In Health,
Dr. Michael Ruscio, DC
Adjunct Professor, University of Bridgeport
Clinical Research

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