January 22, 2025
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Morning Rounds Writer and Podcast Producer
Good morning! It's cold outside and dry dry dry inside the office here at STAT headquarters. It's so bad, I almost considered smearing beef tallow all over my face. (While drafting this newsletter, one editor already reached out asking me not to do this. So, to be clear, I am kidding! But it really is so dry.)

letter to the editor

WHO responds to STAT essay on its internal problems 

Molly Ferguson for STAT

Last week, physician and former White House Covid-19 response coordinator Ashish Jha wrote a First Opinion essay about his belief that the World Health Organization needs “deep reforms,” but that exiting the organization is not the way to enact any needed change. (On Monday, Trump signaled his intent to withdraw through an executive order.)

Yesterday, WHO’s Maria Van Kerkhove wrote a letter to the editor in STAT, responding to Jha’s criticism of the organization. “The scant evidence he cites vastly oversimplifies complex scientific issues and completely overlooks the comprehensive multiyear response that WHO led,” Van Kerkhove wrote. Read the whole letter here.


hospitals

In emergencies, distance makes disease grow stronger

People who live farther from emergency care facilities are more likely to have more complex medical problems when they finally get there, according to a study published yesterday in JAMA Network Open. The study analyzed data from more than 190,000 adults in Florida and California who went to the emergency room for five common general surgical concerns including appendicitis, hernias, and bowel obstruction. 

People in the study who lived more than an hour away from a clinic were more likely to require an operation, get admitted to the hospital, have a longer stay, or require a transfer to another facility as compared to those who lived closer. They also racked up bigger bills.

The study suggests that timeliness could be considered one of the “essential components of health care access,” the authors write. It’s an urgent problem as rural hospitals continue to close all over the country. The authors added that in these areas, future research might be better off using travel time to measure access than ZIP codes. 


first opinion

New guidelines could take a cue from Native American diets

If you’ve kept up with Liz Cooney’s coverage of the 2025 dietary guidelines, then you know that the experts have pointed to plant-based foods as a major component of healthy eating. For generations, many Indigenous communities have already lived this way, relying on what some call the “Three Sisters”: corn, beans, and squash. These veggies in particular have been treated as second-class foods in past dietary guidelines, former Navajo Nation president Jonathan Nez argues in a new First Opinion essay.

That could finally be changing. A scientific report from the committee advising on the new guidelines gives special prominence to plant sources, especially when it comes to protein. Nez argues that codifying this change can right historic wrongs done to Indigenous communities and upgrade federal food policies for everybody. And it’s not just symbolism — the guidelines are used as the basis for many federal nutrition programs, affecting what foods people have access to across the country. Read more.



drug development

Cancer therapy’s new ‘gold rush’

AdobeStock_487144977-1600x900

Adobe 

Immune checkpoint inhibitors have been the MVP of cancer drugs in recent years. Merck’s Keytruda, for example, has been used against dozens of different cancers in millions of patients, making it the top-selling drug in the world. But experts say there’s a new player in town that could eventually challenge the dominance of these first generation treatments. 

Drugs like Keytruda help the immune system to recognize and destroy cancer more aggressively. But a certain type of bispecific antibody — engineered to grab two different antigens at the same time — seems to have hit upon a crucial combination of cancer targets, PD-1 and VEGF. The exact biology isn’t clear yet, but scientists say the approach is promising.

Read more from STAT’s Angus Chen, who lays out the science behind this new approach.


addiction

Women with opioid use disorder aren’t getting as much birth control

Women being treated for opioid use disorder are less likely to be prescribed birth control than those in the general population, according to a study published yesterday in JAMA Internal Medicine. Researchers analyzed commercial insurance claims data from cisgender women ages 18 to 44 between 2016 and 2021. 

While contraceptive prescriptions increased among women in the U.S. generally over the time period, from about 17% to 27%, the prescriptions decreased among those prescribed medications for opioid use disorder, from just over 12% in 2016 to 11.6% in 2021. It’s a sign that people struggling with addiction are not getting integrated, patient-centered birth control counseling as recommended by professional organizations, the authors write.


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What we're reading

  • Trump officials pause health agencies’ communications, citing review, Washington Post
  • Trump's federal health website scrubs 'abortion' search results, NPR

  • Medicare drug price negotiations need something new: a floor, STAT
  • Painful endometriosis can affect the whole body, not only the pelvis, Scientific American
  • Exclusive: Eleos raises $60 million for AI scribe for behavioral health providers, STAT

Thanks for reading! More tomorrow,